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2 edition of study of T lymphocyte subsets in patients with malignant breast disease. found in the catalog.

study of T lymphocyte subsets in patients with malignant breast disease.

David R. McCluskey

study of T lymphocyte subsets in patients with malignant breast disease.

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Published .
Written in English


Edition Notes

Thesis (M.D.)--The Queen"s University of Belfast, 1983.

The Physical Object
Pagination1 v
ID Numbers
Open LibraryOL20340237M


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study of T lymphocyte subsets in patients with malignant breast disease. by David R. McCluskey Download PDF EPUB FB2

In an attempt to identify lymphocyte subsets possibly involved in the response to malignant cells, we have studied the lymphocyte surface phenotype by using a panel of monoclonal antibodies on both peripheral blood lymphocytes (PBL) and histologically proven metastatic and nonmetastatic (i.

"hyperplastic") axillary lymph node lymphocytes (LNL) from eight breast cancer by: 6. 4. T-Lymphocytes and Human Breast Cancer: Friends or Foes.

In humans, the study of the inflammatory infiltrate, mainly T-lymphocytes, has been subject of great interest associated not only with breast cancer [19, 23, 39], but also with other types of neoplasias, including seminoma [40, 41], melanoma [42, 43], colorectal [44, 45], cervical [], ovarian [47, 48], urothelial [], and gastric cancer [].

Cited by: One additional patient with breast cancer experienced a partial regression of disease in lymph nodal and cutaneous sites with complete elimination of malignant cells from a pleural effusion, although cutaneous disease recurred at 4 weeks. This study represents an initial attempt to identify and use lymphocyte subsets with enhanced Cited by:   In breast cancer, humoral immune responses may contribute to clinical outcomes, especially in more immunogenic subtypes.

Here, we investigated B lymphocyte subsets, immunoglobulin expression, and clonal features in breast tumors, focusing on aggressive triple-negative breast cancers (TNBC). In samples from patients with TNBC and healthy volunteers, circulating and.

Introduction. Kidney transplantation improves the quality of life as well as the survival of patients with end-stage renal disease. Although advances in immunosuppressive therapy have markedly prolonged short-term graft survival, long-term graft survival has changed little.

1, 2 Apart from death with a functioning graft, most grafts are lost as the result of a degenerative process Cited by:   Although the favourable role of T lymphocyte populations in different tumour types is established, that of B cells is still a matter of debate and needs further clarification.

The presence of tumour-infiltrating B cells may represent an antibody response against breast tumour antigens.

We used immunohistochemistry to investigate the density and localisation of B lymphocytes infiltrating McCluskey DR, Roy AD, Abram WP, Martin WMC. T Lymphocyte subsets in the peripheral blood of patients with benign and malignant breast disease.

Br J Cancer PubMedCentral PubMed CrossRef Google Scholar. It is difficult to distinguish between lymphocyte subsets on the basis of appearance alone. The malignant T-cell disorders, however, tend to have more convoluted nuclei and may contain azuro-philic granules.

The latter may also be seen in the non-T, non-B large granular lymphocytes or natural killer (NK)cells. Table II Normalperipheral blood. Mean (SD) absolute counts of lymphocytes, CD3 cells, CD3CD4 subsets (T helper) and CD3CD8 subsets (T cytotoxic) in the patient group were () x.

Ghebeh H, Mohammed S, Al-Omair A, et al. The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors.

Neoplasia. ; [Europe PMC free. Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluated the correlations of lymphocyte subsets with clinicopathological and Cited by: 7.

The frequent finding of oligoclonal CD8 T cell expansions in patients with a low tumor mass, but not in patients with advanced disease justifies further work in order to identify the relevance of. The analysis of lymphocyte subsets using fluorochrome labelled monoclonal antibodies and flow cytometry is now routine clinical shown to affect the yield of T lymphocytes from blood samples.

Theadvent ofAIDSas In this study the 35 second cycle was used ensuring optimal monoclonal. In seven of the nine patients, the first blood sample for T-cell subset analysis was drawn after the initiation of treatment.

Patients were followed up for up to days after the acute infection. Fourteen determinations of T-cell subsets were performed in the patients with P. falciparum infections, and 10 in patients with P. vivax infections.

Hodgkin's lymphoma (HL) is a highly curable disease, 1 though the excellent life expectancy is offset by late effects of successful radiotherapy and chemotherapy, particularly the development of second malignancies.

25 Fifteen to 30 years after therapy, cumulative mortality due to all second primary cancers exceeds deaths resulting from HL. 3,68 Breast cancer (BC) accounts for the.

No tumor regressions were noted, but five patients had stable disease. The median survival at the 5 × 10 6 cell dose was 16 months and was not reached at 5 × 10 7 cells, suggesting a possible dose response. In another study, patients were vaccinated with autologous irradiated tumor cells secreting GM-CSF at greater than 40 ng10 6 cells24 hr.

a lymphocyte formed in the bone marrow from which it migrates to the thymic cortex to become an immunologically competent cell; T lymphocytes have long lifespans (months to years) and are responsible for cell-mediated immunity; T lymphocytes form rosettes with sheep erythrocytes and differentiate and divide in the presence of transforming agents (mitogens); T lymphocytes have characteristic T.

Although breast cancer (BC) is not traditionally considered as immunogenic, an increasing number of retrospective and prospective studies have shown that high level of lymphocytes infiltration in BC is associated with improved outcome of patients, particularly in triple negative and HER2-enriched early breast cancer [4, 5, 6].

Medical Intelligence from The New England Journal of Medicine - Novel T-Lymphocyte Population in Combined Immunodeficiency with Features of Graft-versus-Host Disease logo logo   The occurrence of brain metastases in solid tumors is steadily increasing [].

About 50 of cancer patients will experience metastatic spreading to the central nervous system (CNS) in the course of their disease [2,3,4], with the highest incidence been reported in melanoma (), lung (), renal (), and breast cancer () [].

The prognosis and survival of patients with brain. In particular, the lack of signals to attract T lymphocytes or other anti-tumor effector cells may contribute to unchecked tumor progression. Indeed, a sizeable subset of melanomas lack T cell infiltrates (Clemente et al., Erdag et al.).

This observation begs the question of what determines whether a tumor is infiltrated. If patients developed performed on whole blood samples labelled with nausea or dyspepsia uncontrolled by symptomatic monoclonal antibodies against lymphocyte surface Indomethacin, Ranitidine and IL-2 in Advanced Malignant Melanoma markers against T-cell subsets: (CD3, CD4, Intensity of Treatment CD4CD45RA (suppressor-inducer subset.

METHODS: Peripheral blood lymphocyte subsets from 19 patients with oligoarticular JIA (o-JIA), 10 patients with polyarticular JIA (p-JIA), 12 patients with systemic JIA (s-JlA) andfrom 41 age-matched healthy controls were characterized by two color immunofluorescence flow cytometry analysis.

Purpose The cell-surface molecule CD40 activates antigen-presenting cells and enhances immune responses. CD40 is also expressed by solid tumors, but its engagement results in apoptosis. CP, a fully human and selective CD40 agonist monoclonal antibody (mAb), was tested for safety in a phase I dose-escalation study.

Patients and Methods Patients with advanced. Lymphopenia (patients with PTCL-NOS. Because the absolute lymphocyte count easily obtained from the initial complete blood count, it seems to be simple prognostic factors to estimate the prognosis of patients with PTCL-NOS.

The larger scaled study is warranted to confirm our result. The aim of this study was to asses the prognostic significance of lymphocytopenia (very low lymphocytes-cells involved in the immune response), circulating tumor cell (CTC) count in patients with metastatic breast cancer (MBC).

Lymphocytopenia and CTC measurement seem to be independent factors for predicting overall survival in patients with MBC.   1. The prognostic value and practicality of TIL in breast cancer patients with standard treatment Inresearchers developed a method to quantify lymphocyte infiltration in breast cancer.

This method uses standard hematoxylin and eosin (HE) slides from diagnostic breast cancer samples, which is practical, straightforward, and easy to apply. StemVax Therapeutics is a Translational Biotechnology Company that develops novel therapies for brain tumor patients.

We focus our efforts on developing immunotherapeutic approaches to treating patients with Glioblastoma Multiforme (GBM), a devastating brain cancer. We also focus our research efforts on novel drug development to target Cancer.

CD8 T cells (which kill cells expressing foreign or altered antigens), CD4 T cells (which help other T and B lymphocytes do their jobs), and B cells (which make antibodies, proteins that recognize antigens and label cancer cells for destruction by the immune system) from patients with melanoma all expressed lower levels of 24 genes, and higher.

lymphocyte count. Medical Information Search. An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under cellsmicroliter or less than 14 of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms.

Patients with brain malignancies have impaired B and T cell immune function in part due to tumor secreted factors, but greatly due to depressed cellular immunity and increased levels of T regulatory cells [25, 44].

T regulatory cell frequency is increased CD4 T cell subset in lymphopenic patients bearing malignant gliomas [25, 45]. Peripheral. No force of impact this urgent request to host video.

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